North Carolina SB 450: Novel Opioid Control Act of 2025.

Bill Text

GENERAL ASSEMBLY OF NORTH CAROLINA
SESSION 2025
S 1
SENATE BILL 450

Short Title: Novel Opioid Control Act of 2025. (Public)
Sponsors: Senators McInnis, Lazzara, and Sawyer (Primary Sponsors).
Referred to: Rules and Operations of the Senate
March 25, 2025
*S450-v-1*
A BILL TO BE ENTITLED 1
AN ACT TO UPDATE THE CONTROLLED SUBSTANCES ACT. 2
The General Assembly of North Carolina enacts: 3
SECTION 1.(a) G.S. 90-89(1) reads as rewritten: 4
"(1) Opiates. – Any of the following opiates or opioids, including the isomers, 5
esters, ethers, salts and salts of isomers, esters, and ethers, unless specifically 6
excepted, or listed in another schedule, whenever the existence of such 7
isomers, esters, ethers, and salts is possible within the specific chemical 8
designation: 9
... 10
rrr. Brorphine. 11
sss. AP-237. 12
ttt. 2-methyl AP-237. 13
uuu. (ortho, meta, or para)-methyl AP-237. 14
vvv. AP-238. 15
www. (ortho, meta, or para)-hydroxy 2-methyl AP-237. 16
xxx. 2-Naphthyl U-47700. 17
yyy. 1-Naphthyl U-47700. 18
zzz. 4-(Trifluoromethyl) U-47700. 19
aaaa. Methoxy U-47700. 20
bbbb. Furanyl UF-17. 21
cccc. Cyclopropyl U-47700. 22
dddd. Phenyl U-47700. 23
eeee. Ethyl U-47700. 24
ffff. (2,3- or 3,4)-difluoro-N,N-didesmethyl U-47700. 25
gggg. (2,3- or 3,4)-difluoro U-49900. 26
hhhh. (2,3- or 3,4)-difluoro-N-desmethyl U-47700. 27
iiii. 4-fluoro U-47931E. 28
jjjj. (2,3- or 3,4)-difluoro U-51754. 29
kkkk. (2,3- or 3,4)-difluoro Isopropyl U-47700. 30
llll. (2,3- or 3,4)-difluoro Propyl U-47700. 31
mmmm. (2,3- or 3,4)-difluoro U-50488. 32
nnnn. (2,3- or 3,4)-difluoro U-48800. 33
oooo. (2,3- or 3,4 or 2,4)-difluoro U-47700. 34
pppp. UF-17. 35
qqqq. U-47109. 36

General Assembly Of North Carolina Session 2025
Page 2 Senate Bill 450-First Edition
rrrr. U-48520. 1
ssss. N,N-didesmethyl U-47700. 2
tttt. U-62066. 3
uuuu. Propyl U-47700. 4
vvvv. (2,3- or 3,4)-Ethylenedioxy U-51754. 5
wwww. 4-phenyl U-51754. 6
xxxx. N-desmethyl U-47700. 7
yyyy. (2,3- or 3,4)-Ethylenedioxy U-47700. 8
zzzz. N-methyl U-47931E. 9
aaaaa. (2,3- or 3,4)-Methylenedioxy U-47700. 10
bbbbb. U-69593. 11
ccccc. U-50488. 12
ddddd. U-48753E. 13
eeeee. U-47931E. 14
fffff. Butonitazene. 15
ggggg. Etodesnitazene (also known as Etonitazepyne). 16
hhhhh. Flunitazene. 17
iiiii. Metodesnitazene. 18
jjjjj. N-Pyrrolidino Etonitazene. 19
kkkkk. Protonitazene." 20
SECTION 1.(b) G.S. 90-89(1a) reads as rewritten: 21
"(1a) Fentanyl derivatives. – Unless specifically excepted, listed in another 22
schedule, or contained within a pharmaceutical product approved by the 23
United States Food and Drug Administration, any compound structurally 24
derived from N-[1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide 25
(Fentanyl) by any substitution on or replacement of the phenethyl group, any 26
substitution on the piperidine ring, any substitution on or replacement of the 27
propanamide group, any substitution on the anilido phenyl group, or any 28
combination of the above unless specifically excepted or listed in another 29
schedule to include their salts, isomers, and salts of isomers. Fentanyl 30
derivatives include, but are not limited to, the following: 31
... 32
f.33
N-(2-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana34
mide (also known as 2-fluorofentanyl).(also known as 35
ortho-fluorofentanyl). 36
g.37
N-(3-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana38
mide (also known as 3-fluorofentanyl).(also known as 39
meta-fluorofentanyl). 40
h.41
N-(1-phenethylpiperidin-4-yl)-N-phenyltetrahydrofuran-2-carbox42
amide (also known as tetrahydrofuran fentanyl). 43
i.44
N-(4-fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]45
-propanamid e (also known as 4-fluoroisobutyryl fentanyl, 46
4-FIBF).(also known as 4-fluoroisobutyryl fentanyl). 47
j. N-(4-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 48
(also known as 4-fluorobutyryl fentanyl, 4-FBF).(also known as 49
4-fluorobutyryl fentanyl)." 50
SECTION 1.(c) G.S. 90-89 is amended by adding a new subdivision to read: 51

General Assembly Of North Carolina Session 2025
Senate Bill 450-First Edition Page 3
"(1b) Nitazene derivatives. – The N-substituted benzimidazole structural class, 1
including any of the following derivatives, their salts, isomers, or salts of 2
isomers unless specifically utilized as part of the manufacturing process by a 3
commercial industry of a substance or material not intended for human 4
ingestion or consumption, as a prescription administered under medical 5
supervision, or for research at a recognized institution, whenever the existence 6
of these salts, isomers, or salts of isomers is possible within the specific 7
chemical designation or unless specifically excepted or listed in this or another 8
schedule, structurally derived from benzimidazole by substitution at the 9
1-position nitrogen with an ethylamine group, and by substitution at the 10
2-position carbon with a benzyl group, whether or not the compound is further 11
modified in any of the following ways: 12
a.