South Carolina H 5397: Controlled Substances

Bill Text

2025-2026 Bill 5397 Text of Previous Version (Mar. 24, 2026) - South Carolina Legislature Online 

South Carolina General Assembly
126th Session, 2025-2026

Bill 5397

Indicates Matter Stricken
Indicates New Matter

(Text matches printed bills. Document has been reformatted to meet World Wide Web specifications.)

A bill

TO AMEND THE SOUTH 
CAROLINA CODE OF LAWS BY AMENDING SECTION 44-53-190, RELATING TO SCHEDULE I 
CONTROLLED SUBSTANCES, SO AS TO MAKE CERTAIN CHANGES REGARDING SUBSTITUTED 
TRYPTAMINES.

Be it enacted by the 
General Assembly of the State of South Carolina:

SECTION 1. Section 44-53-190(D) of the S.C. Code is amended to 
read:

 (D) Any material, compound, mixture, 
or preparation which contains any quantity of the following hallucinogenic 
substances, their salts, isomers, and salts of isomers, unless specifically 
excepted, whenever the existence of such salts, isomers, and salts of isomers 
is possible within the specific chemical designation:

 1. 3,4-methylenedioxy 
amphetamine

 2. 5-methoxy-3,4-methylenedioxy 
amphetamine

 3. 3,4-methylenedioxymethamphetamine 
(MDMA)

 4. 3,4,5-trimethoxy 
amphetamine

 5. Bufotenine

 6. Diethyltryptamine 
(DET)

 7. Dimethyltryptamine 
(DMT)

 8.5. 4-methyl-2,5-dimethoxyamphetamine 
(STP)

 9.6. Ibogaine

 10.7 Lysergic acid 
diethylamide (LSD)

 11.8. Marijuana

 12.9. Mescaline

 13.10. Peyote

 14.11. N-ethyl-3-piperidyl 
benzilate

 15.12. N-methyl-3-piperidyl 
benzilate

 16.13. Psilocybin

 17.14. Psilocyn

 18.15. Tetrahydrocannabinol 
(THC)

 19.16. 2,5-dimethoxyamphetamine

 20.17. 4-bromo-2,5-dimethoxyamphetamine

 21.18. 4-Methoxyamphetamine

 22.19. Thiophene analog of 
phencyclidine

 23.20. Parahexyl

 24.21. Synthetic 
cannabinoids.-Any material, compound, mixture, or preparation that is not 
listed as a controlled substance in Schedule I through V, is not an 
FDA-approved drug, and contains any quantity of the following substances, their 
salts, isomers (whether optical, positional, or geometric), homologues, and 
salts of isomers and homologues, unless specifically excepted, whenever the 
existence of these salts, isomers, homologues, and salts of isomers and 
homologues is possible within the specific chemical designation:

 a. Naphthoylindoles. 
Any compound containing a 3-(1-naphthoyl)indole structure with substitution at 
the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, 
cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 
2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole 
ring to any extent and whether or not substituted in the naphthyl ring to any 
extent. Including, but not limited to, JWH-015, JWH-018, JWH-019, JWH-073, 
JWH-081, JWH-122, JWH-200, JWH-210, JWH-398, AM-2201, WIN 55-212, AM-2201 (C1 
analog), AM-1220.

 b. Naphthylmethylindoles. 
Any compound containing a 1H-indol-3-yl-(1-naphthyl)methane structure with 
substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, 
alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, 
or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the 
indole ring to any extent and whether or not substituted in the naphthyl ring 
to any extent.

 c. Naphthoylpyrroles. 
Any compound containing a 3-(1-naphthoyl)pyrrole structure with substitution at 
the nitrogen atom of the pyrrole ring by an alkyl, haloalkyl, alkenyl, 
cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 
2-(4-morpholinyl)ethyl group, whether or not further substituted in the pyrrole 
ring to any extent and whether or not substituted in the naphthyl ring to any 
extent. Including, but not limited to, JWH-307, JWH-370, JWH-176.

 d. Naphthylmethylindenes. 
Any compound containing a naphthylideneindene structure with substitution at 
the 3-position of the indene ring by an alkyl, haloalkyl, alkenyl, 
cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 
2-(4-morpholinyl)ethyl group, whether or not further substituted in the indene 
ring to any extent and whether or not substituted in the naphthyl ring to any 
extent.

 e. Phenylacetylindoles. 
Any compound containing a 3-phenylacetylindole structure with substitution at 
the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, 
cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 
2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole 
ring to any extent and whether or not substituted in the phenyl ring to any 
extent. Including, but not limited to, SR-18, RCS-8, JWH-203, JWH-250, JWH-251.

 f. Cyclohexylphenols. 
Any compound containing a 2-(3-hydroxycyclohexyl)phenol structure with 
substitution at the 5-position of the phenolic ring by an alkyl, haloalkyl, 
alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, 
or 2-(4-morpholinyl)ethyl group, whether or not substituted in the cyclohexyl 
ring to any extent. Including, but n